Genetics and molecular biology of Huntington's disease

  title={Genetics and molecular biology of Huntington's disease},
  author={Roger L Albin and Danilo A. Tagle},
  journal={Trends in Neurosciences},
In 1993, the genetic abnormality responsible for Huntington's disease was identified as a trinucleotide-repeat expansion in a novel gene. Much has been learned about the molecular genetics of Huntington's disease and the possible effects of the trinucleotide expansion in the development of this disease and other neurological disorders. The Huntington's disease locus is widely expressed throughout the brain and in many non-neural tissues. Current speculation about the pathogenesis of neuronal… CONTINUE READING

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