Genetics and mammalian transport systems.

@article{Scriver1985GeneticsAM,
  title={Genetics and mammalian transport systems.},
  author={Charles R. Scriver and Harriet S. Tenenhouse},
  journal={Annals of the New York Academy of Sciences},
  year={1985},
  volume={456},
  pages={384-97}
}
Membranes are organelles of homeostasis that control flux and distribution of molecules in cells. Carriers that mediate flux are gene products; mutations that modify carriers are probes that identify their function. Mutations can provide categorical taxonomies of membrane carriers; in higher organisms they can also identify location and characteristics of carriers. Mendelian human phenotypes reveal at least three different systems for the cationic amino acids (lys, orn, arg) segregated in brush… CONTINUE READING

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Mendelian human phenotypes reveal at least three different systems for the cationic amino acids ( lys , orn , arg ) segregated in brush - border ( BBM ) and basolateral ( BLM ) membranes of intestinal and renal epithelia ; carrier(s ) in parenchymal cells ( e.g. fibroblasts ) are not homologous .
Mendelian human phenotypes reveal at least three different systems for the cationic amino acids ( lys , orn , arg ) segregated in brush - border ( BBM ) and basolateral ( BLM ) membranes of intestinal and renal epithelia ; carrier(s ) in parenchymal cells ( e.g. fibroblasts ) are not homologous .
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