Genetics and immunotherapy: using the genetic landscape of gliomas to inform management strategies

@article{Wang2015GeneticsAI,
  title={Genetics and immunotherapy: using the genetic landscape of gliomas to inform management strategies},
  author={Joanna Y. Wang and C Bettegowda},
  journal={Journal of Neuro-Oncology},
  year={2015},
  volume={123},
  pages={373-383}
}
Recent work in genetics has identified essential driver mutations in gliomas and has profoundly changed our understanding of tumorigenesis. New insights into the molecular basis of glioma has informed the development of therapies demonstrating considerable potential, including immunotherapeutic approaches such as peptide and dendritic cell vaccines against EGFRvIII. However, the selective targeting of one component of a dysregulated pathway may be inadequate for a durable clinical response… CONTINUE READING
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