Genetics and immunopathogenesis of IgA nephropathy.

@article{Yu2011GeneticsAI,
  title={Genetics and immunopathogenesis of IgA nephropathy.},
  author={H I Yu and Kuan-Hua Chu and Yao-Hsu Yang and Jyh-Hong Lee and L H Wang and Y C Lin and Bor-Luen Chiang},
  journal={Clinical reviews in allergy & immunology},
  year={2011},
  volume={41 2},
  pages={198-213}
}
IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The hallmark of IgAN is underglycosylation in the hinge region of IgA1. Increasing evidence supports the underglycosylated IgA-containing immune-complex including IgG antibodies against the glycans of the hinge region of IgA1 are key factors for mesangial deposition and then trigger inflammation and glomerular injury. The polymeric IgA is produced after aberrant mucosal IgA response. The displacement of mucosal B cells… CONTINUE READING

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