Genetics and genomics of ankylosing spondylitis.

  title={Genetics and genomics of ankylosing spondylitis.},
  author={Gethin P. Thomas and Matthew A Brown},
  journal={Immunological reviews},
  volume={233 1},
Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of which is poorly understood. The mechanism by which the main gene for the disease, HLA-B27, leads to AS is unknown. Genetic and genomic studies have demonstrated involvement of the interleukin-23 (IL-23) signaling pathway in AS, a finding which has stimulated much new… CONTINUE READING