Genetics and epigenetics of the skin meet deep sequence.

  title={Genetics and epigenetics of the skin meet deep sequence.},
  author={Jeffrey B. Cheng and Raymond J. Cho},
  journal={The Journal of investigative dermatology},
  volume={132 3 Pt 2},
Rapid advances in next-generation sequencing technology are revolutionizing approaches to genomic and epigenomic studies of skin. Deep sequencing of cutaneous malignancies reveals heavily mutagenized genomes with large numbers of low-prevalence mutations and multiple resistance mechanisms to targeted therapies. Next-generation sequencing approaches have already paid rich dividends in identifying the genetic causes of dermatologic disease, both in heritable mutations and the somatic aberrations… CONTINUE READING
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