Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy.

@article{Ho2010GeneticsAC,
  title={Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy.},
  author={Carolyn Y. Ho},
  journal={Circulation},
  year={2010},
  volume={122 23},
  pages={2430-40; discussion 2440}
}
The greatest opportunity afforded by discovering the genetic basis of human heart disease is accurate prediction and prevention of illness. Hypertrophic cardiomyopathy (HCM) provides a paradigm to fulfill this opportunity. Human genetics research has identified many gene mutations that result in cardiac hypertrophy, of which HCM is the most common and well-characterized. Sarcomere gene mutations in HCM result in left ventricular hypertrophy (LVH), myocardial fibrosis and disarray, diastolic… CONTINUE READING

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