Genetics and cell biology of building specific synaptic connectivity.

@article{Shen2010GeneticsAC,
  title={Genetics and cell biology of building specific synaptic connectivity.},
  author={Kang Shen and Peter Scheiffele},
  journal={Annual review of neuroscience},
  year={2010},
  volume={33},
  pages={473-507}
}
The assembly of specific synaptic connections during development of the nervous system represents a remarkable example of cellular recognition and differentiation. Neurons employ several different cellular signaling strategies to solve this puzzle, which successively limit unwanted interactions and reduce the number of direct recognition events that are required to result in a specific connectivity pattern. Specificity mechanisms include the action of contact-mediated and long-range signals… CONTINUE READING
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