Genetics and Epigenetics in Major Psychiatric Disorders

  title={Genetics and Epigenetics in Major Psychiatric Disorders},
  author={Hamid Mostafavi Abdolmaleky and Sam Thiagalingam and Marsha A. Wilcox},
  journal={American Journal of Pharmacogenomics},
No specific gene has been identified for any major psychiatric disorder, including schizophrenia, in spite of strong evidence supporting a genetic basis for these complex and devastating disorders. There are several likely reasons for this failure, ranging from poor study design with low statistical power to genetic mechanisms such as polygenic inheritance, epigenetic interactions, and pleiotropy. Most study designs currently in use are inadequate to uncover these mechanisms. However, to date… 
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This review summarizes recent developments in genetic research into schizophrenia and bipolar disorder, and discusses possible future directions in this field.
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