Genetics: Understanding the ABSOLUTE genome

  • Mina Razzak
  • Published 2012 in Nature Reviews Clinical Oncology


Research led by computational scientists at The Broad Institute in Cambridge, MA, has resulted in ABSOLUTE—a fully quantitative method that can determine tumour purity and cell ploidy of the cancerous cells in a tumour sample. This tool brings scientists closer to pinpointing the precise genetic aberrations in a range of different cancers. Measuring the absolute copy number per cell has hitherto been challenging because of the heterogeneous nature of tumours. Not only are cancerous cells intermixed with normal cells, which can interfere with accurate DNA measurements, but the cancer cell population itself can undergo subclonal evolution. These features have meant that analyses based on DNA mass or other ‘grouped’ methods were inaccurate. ABSOLUTE’s power lies in its ability to essentially measure genome alterations on the cellular level. This calculation is achieved by incorporating models of recurrent cancer karyotypes with relative copy-number data and the genome-wide GENETICS

DOI: 10.1038/nrclinonc.2012.86

Cite this paper

@article{Razzak2012GeneticsUT, title={Genetics: Understanding the ABSOLUTE genome}, author={Mina Razzak}, journal={Nature Reviews Clinical Oncology}, year={2012}, volume={9}, pages={370-370} }