Genetics Talks to Epigenetics? The Interplay Between Sequence Variants and Chromatin Structure

Abstract

Transcription is regulated by two major mechanisms. On the one hand, changes in DNA sequence are responsible for genetic gene regulation. On the other hand, chromatin structure regulates gene activity at the epigenetic level. Given the fundamental participation of these mechanisms in transcriptional regulation of virtually any gene, they are likely to co… (More)
DOI: 10.2174/138920210791616662

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