• Corpus ID: 4681893

Genetics : An Insight to Periodontal Disease

  title={Genetics : An Insight to Periodontal Disease},
  author={Dr. Bushra and Dr. M. L. Bhongade and Dr. Pranav S Patil and Dr Priti Charde},
Periodontal disease is a complex infectious disease resulting from interplay of bacterial infection and host response to bacterial challenge, and the disease is modified by environmental, acquired risk factors and genetic susceptibility. Molecular and Epidemiological studies of the oral microbial flora suggest that, microbial factors responsible for periodontal disease, alone cannot predict the presence or severity of the disease. Therefore, in high-risk patient groups, host susceptibility… 

[Connection Between Genetic Polymorphism of Interleukin -1Beta With Chronic Periodontitis in Peruvian Adults].

The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.



Epigenetics and periodontal disease: future perspectives

Evidence is shown that supports the hypothesis that epigenetic alterations, such as hyper and hypomethylation, of cytokine genes, could help to understand the mechanisms related to periodontal disease activity.

Genetic considerations of risk in human periodontal disease.

  • T. Hart
  • Medicine, Biology
    Current opinion in periodontology
  • 1994
Dissection of a genetic model system forperiodontitis may prove valuable in fully understanding disease pathogenesis in periodontitis, particularly for understanding the role of host susceptibility factors.

Periodontal diseases.

The periodontal diseases are highly prevalent and can affect up to 90% of the worldwide population. Gingivitis, the mildest form of periodontal disease, is caused by the bacterial biofilm (dental

Genes and gene polymorphisms associated with periodontal disease.

  • D. KinaneT. Hart
  • Medicine, Biology
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 2003
It is revealed that, despite major advances in the awareness of genetic risk factors for periodontal disease (with the exception of periodontitis associated with certain monogenetic conditions), the authors are still some way from determining the genetic basis of both aggressive and chronicperiodontitis.

Genetic and inheritance considerations in periodontal disease.

Although specific genetic risk factors have not been identified for the more common adult chronic periodontitis, recent studies indicate that there is significant genetic variance in the population for clinical and radiographic measures of disease.

Genetic influences in caries and periodontal diseases.

  • T. HassellE. L. Harris
  • Medicine, Biology
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1995
A turning point is identified at about 1960, when the periodontal research community turned away from genetics in favor of microbiology research, and investigators have re-initiated the search for the hereditary component in susceptibility to common adultperiodontal disease.

Genetic susceptibility to periodontitis.

It is concluded that there are differences among the various studies for the rare allele carriage rates and future studies should apply stricter disease classifications, use larger study cohorts, adjust for relevant risk factors in aggressive and chronic periodontiti,s and include analysis of multiple genes and polymorphisms.

Periodontal disease in Down's syndrome: a review.

The altered immune response together with higher calculus scores may explain the difference in severity of periodontal disease between institutionalized DS children and those living at home.