Genetics: Taking single-cell transcriptomics to the bedside

  title={Genetics: Taking single-cell transcriptomics to the bedside},
  author={Sam Behjati and Muzlifah Haniffa},
  journal={Nature Reviews Clinical Oncology},
cancers have begun to provide insights into the wealth of biological information encoded in tumour mRNA1. Along with wholegenome DNA sequences, thousands of tumour transcrip tomes have been interrogated over the past decade. These analyses, however, have been performed only on bulk tumour tissue. Importantly, the cancer transcriptome is the sum of its individual components: that is, transcriptomically diverse individual tumour cells admixed with nonmalignant cells. By contrast, the somatic… CONTINUE READING

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