Genetics, transcriptomics, and proteomics of Alzheimer's disease.

  title={Genetics, transcriptomics, and proteomics of Alzheimer's disease.},
  author={Andreas Papassotiropoulos and Michael Fountoulakis and Travis Dunckley and Dietrich A. Stephan and Eric M. Reiman},
  journal={The Journal of clinical psychiatry},
  volume={67 4},
OBJECTIVE To provide an updated overview of the methods used in genetic, transcriptomic, and proteomic studies in Alzheimer's disease and to demonstrate the importance of those methods for the improvement of the current diagnostic and therapeutic possibilities. DATA SOURCES MEDLINE-based search of 233 peer-reviewed articles published between 1975 and 2006. DATA SYNTHESIS Alzheimer's disease is a genetically heterogeneous disorder. Rare mutations in the amyloid precursor protein, presenilin… CONTINUE READING