Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study.

@article{Zheng1996GeneticallyUC,
  title={Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study.},
  author={Min-qiao Zheng and Xuanwei Huang and Gary. Smith and Xiaohua Yang and Xinfa Gao},
  journal={Journal of molecular biology},
  year={1996},
  volume={264 2},
  pages={
          323-36
        }
}
Recent molecular genetics studies have revealed a correlation between spontaneous, progressive expansion of several DNA trinucleotide repeats and certain hereditary neurodegenerative diseases. Triplet repeat (TR) sequences may be present in structured forms that can mediate the processes interrupting normal cellular replication, transcription, or repair activities, eventually leading to gene mutation. Using high resolution NMR spectroscopy and other biophysical methods, we probed the solution… CONTINUE READING
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Structural studies of CNG repeats

Nucleic acids research • 2014
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