Genetically structured models for lac promoter-operator function in the chromosome and in multicopy plasmids: Lac promoter function.

@article{Lee1984GeneticallySM,
  title={Genetically structured models for lac promoter-operator function in the chromosome and in multicopy plasmids: Lac promoter function.},
  author={Sun Bok Lee and J. E. Bailey},
  journal={Biotechnology and bioengineering},
  year={1984},
  volume={26 11},
  pages={1383-9}
}
A mathematical model based on molecular mechanisms for regulation of the lactose (lac) operon in Escherichia coli has been extended and applied to investigate the lac promoter function in the chromosome and in multicopy plasmids. The model simulates the influence of certain host cell mutations and also mutations in the lac promoter sequence in the chromosome in reasonable agreement with previous experimental measurements. The effect of the plasmid copy number and the cloning vector size on the… CONTINUE READING

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