Genetically simpler bovine leukemia virus derivatives can replicate independently of Tax and Rex.

@article{BorisLawrie1995GeneticallySB,
  title={Genetically simpler bovine leukemia virus derivatives can replicate independently of Tax and Rex.},
  author={Kathleen Boris-Lawrie and Howard M. Temin},
  journal={Journal of virology},
  year={1995},
  volume={69 3},
  pages={
          1920-4
        }
}
  • Kathleen Boris-Lawrie, Howard M. Temin
  • Published in Journal of virology 1995
  • Biology, Medicine
  • Retrovirus genomes have a conserved modular organization that consists of trans-acting gag, pol, and env genes that function through cis-acting sequences to replicate the RNA genome to the DNA provirus. Genetically more complex retroviruses also encode regulatory genes and cis-acting sequences that are essential for their replication. We sought to convert a more complex retrovirus into a simpler retrovirus derivative that can replicate. We constructed novel, hybrid retrovirus vectors to… CONTINUE READING

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