Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection.

@article{Monteforte2000GeneticallyRM,
  title={Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection.},
  author={Gina M. Monteforte and Kozue Takeda and Miriam Rodriguez-Sosa and Shizuo Akira and John R. David and Abhay R Satoskar},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={5890-3}
}
IL-18 has been shown to play a critical role in the development of a Th1 response and immunity against intracellular pathogens. To determine the role of IL-18 in the development of protective immunity against Leishmania major, we have analyzed the course of cutaneous L. major in IL-18-deficient C57BL/6 mice (IL-18-/-) compared with similarly infected wild-type mice (IL-18+/+). After L. major infection, IL-18-/- mice may develop larger lesions during early phase of infection but eventually will… CONTINUE READING

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