Genetically predicted 17β-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study.

@article{Zhao2014GeneticallyP1,
  title={Genetically predicted 17β-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study.},
  author={Jie V Zhao and Chaoqiang Jiang and Tai Hing Lam and Bing Liu and Kevin K.T. Cheng and Sushma Kavikondala and Wei Zhang and Gabriel M. Leung and C. Mary Schooling},
  journal={Journal of epidemiology and community health},
  year={2014},
  volume={68 8},
  pages={
          780-5
        }
}
BACKGROUND Many chronic diseases are characterised by low-grade systemic inflammation. Oestrogens may promote immune response consistent with sex-specific patterns of diseases. In vitro culture and animal experiments suggest oestrogens are anti-inflammatory and might thereby protect against low-grade systemic inflammation. Evidence from epidemiological studies is limited. Using a Mendelian randomisation analysis with a separate-sample instrumental variable (SSIV) estimator, we examined the… CONTINUE READING
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