Genetically modified mouse models for oral drug absorption and disposition.

  title={Genetically modified mouse models for oral drug absorption and disposition.},
  author={Seng Chuan Tang and Jeroen J. M. A. Hendrikx and Jos H. Beijnen and Alfred H Schinkel},
  journal={Current opinion in pharmacology},
  volume={13 6},
Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them. These studies showed that Multidrug resistance-associated protein 2 (Mrp2) can limit intestinal drug absorption. Organic cation transporter n1 (Octn1) and Octn2 might also facilitate intestinal drug absorption, although direct in vivo… CONTINUE READING

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