Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms.

@article{OTuathaigh2014GeneticallyMM,
  title={Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms.},
  author={Colm M P O'Tuathaigh and Lieve Desbonnet and John L Waddington},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2014},
  volume={24 5},
  pages={800-21}
}
Modelling negative symptoms in any animal model, particularly in mice mutant for genes related to schizophrenia, is complicated by the absence of the following key elements that might assist in developing validation criteria: clinical clarity surrounding this symptom constellation; any clear association between negative symptoms and pathological signature(s) in the brain; and therapeutic strategies with material clinical efficacy against these symptoms. In this review, the application of mutant… CONTINUE READING
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