Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma

@inproceedings{Guo2015GeneticallyM,
  title={Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma},
  author={Zhu-Ling Guo and Bin Yu and Bo-tao Ning and Shing Po Chan and Qiu-Bin Lin and James Chun-bong Li and Jian-Dong Huang and Godfrey Chi-fung Chan},
  booktitle={Journal of hematology & oncology},
  year={2015}
}
BACKGROUND Neuroblastoma currently has poor prognosis, therefore we proposed a new strategy by targeting neuroblastoma with genetically engineered anaerobic Salmonella (Sal-YB1). METHODS Nude and nonobese diabetic-severe combined immunodeficiency (NOD-SCID) orthotopic mouse models were used, and Sal-YB1 was administered via tail vein. The therapeutic… CONTINUE READING