Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts.

@article{Zhang2010GeneticallyMP,
  title={Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts.},
  author={Dongsheng Zhang and Wei Huang and Bingze Dai and Tiemin Zhao and Atif Ashraf and RonaldW. Millard and Muhammad Sohaib Ashraf and Yigang Wang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 5},
  pages={
          H1339-47
        }
}
We postulated that the combination of overexpression of CXCR4 in mesenchymal stem cells (MSC) with diprotin A would enhance MSC recruitment and penetration into ischemic myocardium, leading to an improvement in heart function after myocardial infarction (MI). Male rat MSC were genetically engineered with adenoviral vectors coexpressing CXCR4 and enhanced green fluorescent protein (EGFP) (MSC(CXCR4)), GFP alone (MSC(Null), control), or siRNA-targeted CXCR4 (MSC(siRNA)). Cell sheets were applied… CONTINUE READING

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