Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.

@article{Umanskaya2014GeneticallyEM,
  title={Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.},
  author={Alisa Umanskaya and Gaetano Santulli and Wenjun Xie and Daniel C. Andersson and Steven R. Reiken and Andrew Robert Marks},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 42},
  pages={15250-5}
}
Age-related skeletal muscle dysfunction is a leading cause of morbidity that affects up to half the population aged 80 or greater. Here we tested the effects of increased mitochondrial antioxidant activity on age-dependent skeletal muscle dysfunction using transgenic mice with targeted overexpression of the human catalase gene to mitochondria (MCat mice). Aged MCat mice exhibited improved voluntary exercise, increased skeletal muscle specific force and tetanic Ca(2+) transients, decreased… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS
52 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107

  • Y Mei
  • PLoS ONE
  • 2013

Similar Papers

Loading similar papers…