Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.

  title={Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.},
  author={Alisa Umanskaya and Gaetano Santulli and Wenjun Xie and Daniel C. Andersson and Steven R. Reiken and Andrew Robert Marks},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 42},
Age-related skeletal muscle dysfunction is a leading cause of morbidity that affects up to half the population aged 80 or greater. Here we tested the effects of increased mitochondrial antioxidant activity on age-dependent skeletal muscle dysfunction using transgenic mice with targeted overexpression of the human catalase gene to mitochondria (MCat mice). Aged MCat mice exhibited improved voluntary exercise, increased skeletal muscle specific force and tetanic Ca(2+) transients, decreased… CONTINUE READING
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