Genetically engineered pig models for human diseases.

@article{Prather2013GeneticallyEP,
  title={Genetically engineered pig models for human diseases.},
  author={Randall S Prather and Monique A. Lorson and Jason W Ross and Jeffrey J. Whyte and E. Garrison Walters},
  journal={Annual review of animal biosciences},
  year={2013},
  volume={1},
  pages={
          203-19
        }
}
Although pigs are used widely as models of human disease, their utility as models has been enhanced by genetic engineering. Initially, transgenes were added randomly to the genome, but with the application of homologous recombination, zinc finger nucleases, and transcription activator-like effector nuclease (TALEN) technologies, now most any genetic change that can be envisioned can be completed. To date these genetic modifications have resulted in animals that have the potential to provide new… CONTINUE READING
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