Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis.

@article{Tazawa2012GeneticallyEO,
  title={Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis.},
  author={Hiroshi Tazawa and Shuya Yano and Ryosuke Yoshida and Yasumoto Yamasaki and Tsuyoshi Sasaki and Yuuri Hashimoto and Shinji Kuroda and Masaaki Ouchi and Teppei Onishi and Futoshi Uno and Shunsuke Kagawa and Yasuo Urata and Toshiyoshi Fujiwara},
  journal={International journal of cancer},
  year={2012},
  volume={131 12},
  pages={2939-50}
}
Autophagy is known to have a cytoprotective role under various cellular stresses; however, it also results in robust cell death as an important safeguard mechanism that protects the organism against invading pathogens and unwanted cancer cells. Autophagy is regulated by cell signalling including microRNA (miRNA), a post-transcriptional regulator of gene expression. Here, we show that genetically engineered telomerase-specific oncolytic adenovirus induced miR-7 expression, which is significantly… CONTINUE READING
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Genetically engineered oncolytic adenovirus induces autophagic cell death through an E 2 F 1microRNA7epidermal growth factor receptor axis

  • H Tazawa, S Yano, +9 authors Y Urata
  • Int J Cancer
  • 2012

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