Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology.

@article{Mazur2012GeneticallyEM,
  title={Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology.},
  author={Pawel K. Mazur and Jens T. Siveke},
  journal={Gut},
  year={2012},
  volume={61 10},
  pages={1488-500}
}
Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease despite tremendous scientific efforts. Numerous trials have failed to improve the outcome on this deadliest of all major cancers. Potential causes include a still insufficient understanding of key features of this cancer and imperfect preclinical models for identification of active agents and mechanisms of therapeutic responses and resistance. Modern genetically engineered mouse models of PDAC faithfully recapitulate the… CONTINUE READING