Genetically engineered mouse models in oncology research and cancer medicine

  title={Genetically engineered mouse models in oncology research and cancer medicine},
  author={Kelly Kersten and Karin E. de Visser and Martine H van Miltenburg and Jos Jonkers},
  booktitle={EMBO molecular medicine},
Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune-proficient microenvironment. Tumors arising in advanced GEMMs closely mimic the histopathological and molecular features of their human counterparts, display genetic heterogeneity, and are able to spontaneously progress toward metastatic disease. As such, GEMMs are generally superior to cancer… CONTINUE READING
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