Genetically engineered models with alterations in cardiac membrane calcium-handling proteins.

@article{Kiriazis2000GeneticallyEM,
  title={Genetically engineered models with alterations in cardiac membrane calcium-handling proteins.},
  author={Helen Kiriazis and Evangelia G Kranias},
  journal={Annual review of physiology},
  year={2000},
  volume={62},
  pages={321-51}
}
Regulation of intracellular Ca2+ provides a means by which the strength and duration of cardiac muscle contraction is altered on a beat-to-beat basis. Ca2+ homeostasis is maintained by proteins of the outer cell membrane or sarcolemma and the sarcoplasmic reticulum, which is the major intracellular Ca2+ storage organelle. Recently, genetic engineering techniques designed to induce specific mutations, manipulate expression levels, or change a particular isoform of various membrane Ca(2… CONTINUE READING
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