Genetically engineered endothelial cells remain adherent and viable after stent deployment and exposure to flow in vitro.

@article{Flugelman1992GeneticallyEE,
  title={Genetically engineered endothelial cells remain adherent and viable after stent deployment and exposure to flow in vitro.},
  author={Moshe Y Flugelman and Renu Virmani and Martin B. Leon and Robert L. Bowman and David A. Dichek},
  journal={Circulation research},
  year={1992},
  volume={70 2},
  pages={348-54}
}
Intravascular stents, currently in experimental human use for recurrent arterial stenosis, are plagued by subacute thrombosis. As a therapeutic approach to stent-related thrombosis, we and others have suggested coating stents with endothelial cells before implantation. In a previous study we demonstrated the feasibility of coating stents with endothelial cells that were genetically modified to secrete large amounts of human tissue plasminogen activator. In the present study we attempted both to… CONTINUE READING

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