Genetically engineered avidins and streptavidins

@article{Laitinen2006GeneticallyEA,
  title={Genetically engineered avidins and streptavidins},
  author={Olli H. Laitinen and Vesa Pekka Hyt{\"o}nen and Henri R. Nordlund and Markku S. Kulomaa},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2992-3017}
}
Abstract.Chicken avidin and bacterial streptavidin, (strept)avidin, are proteins widely utilized in a number of applications in life science, ranging from purification and labeling techniques to diagnostics, and from targeted drug delivery to nanotechnology. (Strept)avidin-biotin technology relies on the extremely tight and specific affinity between (strept)avidin and biotin (dissociation constant, Kd≈10−14–10−16 M). (Strept)avidins are also exceptionally stable proteins. To study their ligand… 

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