Genetically engineered T cells for the treatment of cancer

  title={Genetically engineered T cells for the treatment of cancer},
  author={Magnus Essand and Angelica Loskog},
  booktitle={Journal of internal medicine},
T-cell immunotherapy is a promising approach to treat disseminated cancer. However, it has been limited by the ability to isolate and expand T cells restricted to tumour-associated antigens. Using ex vivo gene transfer, T cells from patients can be genetically engineered to express a novel T cell receptor or chimeric antigen receptor to specifically recognize a tumour-associated antigen and thereby selectively kill tumour cells. Indeed, genetically engineered T cells have recently been… CONTINUE READING
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