Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer.

@article{Nguyen2010GeneticallyES,
  title={Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer.},
  author={Vu Hong Nguyen and Hyung-Seok Kim and Jung-Min Ha and Yeongjin Hong and Hyon E Choy and Jung-Joon Min},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={18-23}
}
Tumor-targeting bacteria have been studied in terms of their ability to visualize the infection pathway (through imaging probes) or to carry therapeutic molecules to tumors. To integrate these monitoring and therapeutic functions, we engineered attenuated Salmonella typhimurium defective in guanosine 5'-diphosphate-3'-diphosphate synthesis to carry cytotoxic proteins (cytolysin A) and express reporter genes. We successfully visualized the therapeutic process with these engineered bacteria in… CONTINUE READING

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