Genetically engineered Salmonella Typhimurium: Recent advances in cancer therapy.

@article{Liang2019GeneticallyES,
  title={Genetically engineered Salmonella Typhimurium: Recent advances in cancer therapy.},
  author={Kang Liang and Qing Liu and Pei Li and Hongyan Luo and Haoju Wang and Qingke Kong},
  journal={Cancer letters},
  year={2019},
  volume={448},
  pages={
          168-181
        }
}
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38 Citations
Highly Influential Citations
3
Background Citations
7
Methods Citations
1
Results Citations
1

38 Citations

Citation Type

Citation Type

New technologies in developing recombinant‐attenuated bacteria for cancer therapy
TLDR
A review of new technologies or approaches that may improve bacteria‐mediated cancer therapy by focusing on the generation of attenuated bacterial strains with higher targeting for tumor tissue, and optimization of the delivery of therapeutic antitumor cargoes into the tumor microenvironment.
Optimized Attenuated Salmonella Typhimurium Suppressed Tumor Growth and Improved Survival in Mice
TLDR
It is demonstrated that the beneficial anti-tumor efficacy of attenuated S. Typhimurium bacteria could be improved through delivery of drug molecules with powerful anti-Tumor activities.
Pseudomonas aeruginosa in Cancer Therapy: Current Knowledge, Challenges and Future Perspectives
TLDR
P. aeruginosa, a Gram-negative bacterial pathogen, is one of the common bacteria used in development of bacteria-based cancer therapy, particularly known for the Pseudomonas exotoxin A-based immunotoxins, which have shown remarkable anti-tumor efficacy and specificity.
Highlights of Immunomodulation in Salmonella-Based Cancer Therapy
TLDR
Modifications of Salmonella-based treatment in the attempt to improve tumor-specific immune responses including cytokine therapy, gene therapy, and DNA vaccine delivery are discussed.
Construction and investigation of plasmid-induced effects on growth of GFP-expressing Salmonella strains
TLDR
GFP-transformed Salmonella, specifically the BDLA S. Agona strain, could be utilised as a powerful tool for future studies on the mechanism of tumour suppression and real-time in vivo biodistribution of the strain.
Bacteria-cancer interactions: bacteria-based cancer therapy
TLDR
Live tumor-targeting bacteria can selectively induce cancer regression and, with the help of genetic engineering, be made safe and effective vehicles for delivering drugs to tumor cells.
Bacterial-based cancer therapy: An emerging toolbox for targeted drug/gene delivery.
Current Status and Future Directions of Bacteria-Based Immunotherapy
TLDR
This review will cover the inherent advantages of unedited bacteria, highlight how bacteria can be engineered to provide greater tumor-targeting properties, enhanced immune-modulation effect, and improved safety, and highlight the future directions and potential opportunities of this emerging field.
Innovative Approaches of Engineering Tumor-Targeting Bacteria with Different Therapeutic Payloads to Fight Cancer: A Smart Strategy of Disease Management
TLDR
The mechanism by which bacteria sense tumor microenvironment, role of some anticancer agents, and the recent advancement of engineering bacteria with different therapeutic payloads to combat cancers has been reviewed.
Integration of Salmonella into Combination Cancer Therapy
TLDR
The advantages that make Salmoneella a good candidate for combination cancer therapy are described and the findings of representative studies that aimed to investigate the therapeutic outcome of combination therapies involving Salmonella are summarized.
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References

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