Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.

@article{Leung2008GeneticallyEP,
  title={Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.},
  author={Daisy W Leung and Chinatsu Otomo and Joanne Chory and Michael K Rosen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 35},
  pages={12797-802}
}
General methods to engineer genetically encoded, reversible, light-mediated control over protein function would be useful in many areas of biomedical research and technology. We describe a system that yields such photo-control over actin assembly. We fused the Rho family GTPase Cdc42 in its GDP-bound form to the photosensory domain of phytochrome B (PhyB) and fused the Cdc42 effector, the Wiskott-Aldrich Syndrome Protein (WASP), to the light-dependent PhyB-binding domain of phytochrome… CONTINUE READING

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