Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia

Abstract

Visualization of signal transduction in live primary cilia constitutes a technical challenge owing to the organelle's submicrometer dimensions and close proximity to the cell body. Using a genetically encoded calcium indicator targeted to primary cilia, we visualized calcium signaling in cilia of mouse fibroblasts and kidney cells upon chemical or… (More)
DOI: 10.1038/nmeth.2647

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