Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.

Abstract

BACKGROUND & AIMS The biological aggressiveness of hepatocellular carcinoma (HCC) and the lack of optimal therapeutic strategies have rendered the disease a major challenge. Highly heterogeneous genetic alteration profiles of HCC have made it difficult to identify effective tailor-made molecular therapeutic targets. Therefore, classification of HCC into… (More)

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