Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.

@article{Liu2008GeneticallyDP,
  title={Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.},
  author={Jie Liu and Praveen B Gurpur and Stephen J. Kaufman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 51},
  pages={35668-78}
}
The dystrophin-glycoprotein complex and the alpha7beta1 integrin are trans-sarcolemmal linkage systems that connect and transduce contractile forces between muscle fibers and the extracellular matrix. alpha7beta1 is the major laminin binding integrin in skeletal muscle. Different functional variants of this integrin are generated by alternative splicing and post-translational modifications such as glycosylation and ADP-ribosylation. Here we report a species-specific difference in alpha7 chains… CONTINUE READING

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