Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.

@article{Jnsen2007GeneticallyDM,
  title={Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.},
  author={Andreas J{\"o}nsen and B Gullstrand and Nuray G{\"u}ner and A A Bengtsson and Ola Nived and Lennart Truedsson and Gunnar K Sturfelt},
  journal={Lupus},
  year={2007},
  volume={16 4},
  pages={245-53}
}
Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe infections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Damage Index regarding cerebrovascular accidents, angina pectoris, coronary by-pass surgery, myocardial infarction and peripheral arterial disease leading to significant tissue loss… CONTINUE READING