Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect.

@article{FunckBrentano1989GeneticallydeterminedIB,
  title={Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect.},
  author={C. Funck-Brentano and H. Kroemer and H. Pavlou and R. Woosley and D. Roden},
  journal={British journal of clinical pharmacology},
  year={1989},
  volume={27 4},
  pages={
          435-44
        }
}
1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug propafenone, depend on the isozyme responsible for debrisoquine 4-hydroxylation. 2. The effect of quinidine on the debrisoquine phenotype-dependent 5-hydroxylation and the pharmacological activity of propafenone was studied in seven 'extensive' metabolizers and two 'poor' metabolizers of the drug… Expand
Clinical Pharmacokinetics of Propafenone
Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin.
Combined Administration of Quinidine and Propafenone for Atrial Fibrillation: The CAQ‐PAF Study
Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Potent electrophysiologic effects of the major metabolites of propafenone in canine Purkinje fibers.
...
1
2
3
4
...