Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis.

@article{Pender1998GeneticallyDF,
  title={Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis.},
  author={Michael P. Pender},
  journal={Lancet},
  year={1998},
  volume={351 9107},
  pages={978-81}
}
I postulate that multiple sclerosis is an autoimmune disease that involves genetically determined failure of activation-induced apoptosis of autoreactive T cells in the central nervous system. Activation of central-nervous-system-reactive T cells in peripheral lymphoid organs by exposure to crossreacting antigens or superantigens derived from common infectious agents may trigger attacks of multiple sclerosis. In normal individuals these activated T cells are deleted by activation-induced… CONTINUE READING

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