Genetically defined mouse models that mimic natural aspects of human prostate cancer development.

  title={Genetically defined mouse models that mimic natural aspects of human prostate cancer development.},
  author={Pradip Roy-Burman and Hui-Ann Wu and William C. Powell and Jill M. Hagenkord and Michael B. Cohen},
  journal={Endocrine-related cancer},
  volume={11 2},
This review is focused on mouse models for prostate cancer that have been designed on the basis of genetic alterations that are frequently found in human prostate cancer. It begins with an analysis of the similarities and differences in the gross and microscopic anatomy of the mouse and human prostate glands, and extends to the pathologies induced in the genetically manipulated mouse prostate in comparison with the sporadic development of the disease in humans. Major achievements have been made… CONTINUE READING

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