Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.

@article{Lim2014GeneticallyAO,
  title={Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.},
  author={M. A. Lim and K. Bence and Ishani Sandesara and P{\'e}n{\'e}lope A. Andreux and J. Auwerx and Jeff Ishibashi and P. Seale and R. Kalb},
  journal={Human molecular genetics},
  year={2014},
  volume={23 18},
  pages={
          4995-5008
        }
}
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that causes death of motor neurons. ALS patients and mouse models of familial ALS display organismal level metabolic dysfunction, which includes increased energy expenditure despite decreased lean mass. The pathophysiological relevance of abnormal energy homeostasis to motor neuron disease remains unclear. Leptin is an adipocyte-derived hormone that regulates whole-animal energy expenditure. Here, we report that placing… Expand
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