Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

@inproceedings{Mizrak2013GeneticallyEM,
  title={Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth},
  author={Arda Mizrak and Mehmet Fatih Bolukbasi and Gokhan Baris Ozdener and Gary J. Brenner and Sibylle Madlener and Erdogan Pekcan Erkan and Thomas Stroebel and Xandra O Breakefield and Okay Saydam},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013}
}
Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell to cell. To our knowledge, this is the first report of delivery of a therapeutic mRNA/protein via MVs for treatment of cancer. We first generated genetically engineered MVs by expressing high levels of the suicide gene mRNA and protein-cytosine deaminase (CD) fused to uracil phosphoribosyltransferase (UPRT) in MV donor cells. MVs were… CONTINUE READING
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