Genetically Encoded Protein Sensors of Membrane Potential.

  title={Genetically Encoded Protein Sensors of Membrane Potential.},
  author={Douglas A. Storace and Masoud Sepehri Rad and Zhou Han and Lei Jin and Lawrence Berel Cohen and Thomas E Hughes and Bradley J. Baker and Uhna Sung},
  journal={Advances in experimental medicine and biology},
Organic voltage-sensitive dyes offer very high spatial and temporal resolution for imaging neuronal function. However these dyes suffer from the drawbacks of non-specificity of cell staining and low accessibility of the dye to some cell types. Further progress in imaging activity is expected from the development of genetically encoded fluorescent sensors of membrane potential. Cell type specificity of expression of these fluorescent protein (FP) voltage sensors can be obtained via several… CONTINUE READING
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