Genetic vs Environmental Factors That Correlate With Rosacea: A Cohort-Based Survey of Twins.

  title={Genetic vs Environmental Factors That Correlate With Rosacea: A Cohort-Based Survey of Twins.},
  author={Nely Z Aldrich and Meg R. Gerstenblith and Pingfu Fu and Marie S Tuttle and Priya K. Varma and Erica Gotow and Kevin D. Cooper and Margaret W. Mann and Daniel L. Popkin},
  journal={JAMA dermatology},
  volume={151 11},
IMPORTANCE To our knowledge, this is the first study on rosacea to formally define genetic and environmental contributions. OBJECTIVES To study a cohort of identical and fraternal twins to determine whether genetic factors contribute to rosacea development and, if genetic factors are present, quantitatively estimate the genetic contribution, as well as to identify environmental factors that correlate with rosacea by controlling for genetic susceptibility. DESIGN, SETTING, AND PARTICIPANTS… 

Figures and Tables from this paper

Intrafamilial Transmission of Rosacea Spanning Six Generations: A Retrospective Observational Study.
Extending the search to all potential affected parents and offspring of rosacea patients can promote early diagnosis along with the adoption of correct therapeutic interventions and educational programs to prevent the exposure to triggering or exacerbating factors.
Rosacea Epidemiology and Genetics
Although rare, childhood rosacea should be recognized, Rosacea in childhood is more frequently associated with ocular involvement, which may represent the only manifestation of the disease in this age group.
Association between rosacea severity and relative muscle mass: A cross‐sectional study
Relative muscle mass is negatively associated with an increased risk of more severe rosacea, suggesting that skeletal muscle can have a protective effect onrosacea exacerbation.
Obesity and risk for incident rosacea in US women
Clustering of autoimmune diseases in patients with rosacea.
Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes
The identified loci provide specificity of inflammatory mechanisms in rosacea, and identify potential pathways for therapeutic intervention.
Rosacea and Chronic Systemic Diseases: Case-ControlStudy in Saudi Arabia
Rosacea is associated with numerous systemic comorbid diseases in patients attending the dermatology clinic at King Fahd Hospital of the University and associated medical conditions were self-reported confirmed either by medications use or medical records.
Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO)
These cohorts will help uncover potential disease overlaps and allow for prolonged follow-up through national Danish health registers and serve as strong data sources that will be used for future studies on rosacea and migraine with focus on risk factors, occurrence, treatment, natural history, complications, comorbidities and prognosis.
Characterization of the facial microbiome in twins discordant for rosacea
A significant correlation between facial microbiome and severity of rosacea in genetically matched twins is demonstrated and importantly that overall microbiome composition is largely unchanged.
Ethnicity versus Climate: The Impacts of Genetics and Environment on Rosacea Epidemiology and Pathogenesis
The roles of cold-induced vasodilation, the skin colonization by Demodex mites, and the findings from the most recent genetic studies in this field are discussed.


The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women.
The evidence of a major genetic influence on acne should stimulate the search for potential genes that may lead to new therapeutic approaches, and the lower serum levels of apolipoprotein A1 in acne twins were confirmed when analyzing acne discordant twin pairs.
[Epidemiology of rosacea: updated data].
The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data
The twin model is also ideal for the new field of epigenetics, investigating subtle differences in DNA methylation within discordant MZ pairs for a disease, as well as differences in CNVs.
Prevalence of premature ovarian failure in monozygotic and dizygotic twins.
Despite some striking differences within MZ twin-pairs, menopausal ages were more concordant than for DZ twins, confirming that the timing of menopause has a heritable component.
New insights into rosacea pathophysiology: a review of recent findings.
Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea.
The National Rosacea Society assembled a committee to develop a standard classification system that can serve as a diagnostic instrument to investigate the manifestations and relationships of the several subtypes and potential variants of rosacea.
Testicular cancer in twins: a meta-analysis
In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1–1.6), providing indirect support for the hypothesis that in utero hormone variations
Risk factors associated with rosacea
This study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for rosacea, which can be a precursor to the disease.
The validity and practicality of sun-reactive skin types I through VI.
It was decided that a brief personal interview regarding the history of the person's unburn and suntan experience was one approach to estirnate the skin tolerance to uitraviolet radiation (UVR) exposure.