Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading.

@article{Squire2004GeneticVT,
  title={Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading.},
  author={Maria E Squire and Leah-Rae Donahue and Clinton T. Rubin and Stefan Judex},
  journal={Bone},
  year={2004},
  volume={35 6},
  pages={1353-60}
}
Genetics can substantially influence bone morphology and may define the skeleton's response to mechanical unloading. Recent data indicated that disuse produces different site-specific responses in the skeleton of genetically distinct adult female C3H/HeJ (C3H) and BALB/cByJ (BALB) mice; while disuse BALB mice had significantly less bone than age-matched controls in the distal and diaphyseal femur, the removal of weight bearing had a much smaller influence in C3H. Using adult male mice from… CONTINUE READING

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