Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1

@inproceedings{Palaniswamy2009GeneticVR,
  title={Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1},
  author={Ramesh Palaniswamy and Stephan Teglund and Matthias Lauth and Peter G. Zaphiropoulos and Takashi Shimokawa},
  booktitle={BMC Molecular Biology},
  year={2009}
}
Alternative splicing is one of the key mechanisms that generate biological diversity. Even though alternative splicing also occurs in the 5' and 3' untranslated regions (UTRs) of mRNAs, the understanding of the significance and the regulation of these variations is rather limited. We investigated 5' UTR mRNA variants of the mouse Gli1 oncogene, which is the terminal transcriptional effector of the Hedgehog (HH) signaling pathway. In addition to identifying novel transcription start sites, we… CONTINUE READING

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  • October 2009 Accepted:
  • 2010
1 Excerpt

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