Genetic variations of hepatitis B virus and serum aflatoxin-lysine adduct on high risk of hepatocellular carcinoma in Southern Guangxi, China.

@article{Xu2010GeneticVO,
  title={Genetic variations of hepatitis B virus and serum aflatoxin-lysine adduct on high risk of hepatocellular carcinoma in Southern Guangxi, China.},
  author={Li Xu and Guoqing Qian and Lili Tang and Jianjia Su and Jia-sheng Wang},
  journal={Journal of hepatology},
  year={2010},
  volume={53 4},
  pages={
          671-6
        }
}
BACKGROUND & AIMS Southern Guangxi area is one of the endemic areas for hepatocellular carcinoma (HCC) in China. This study evaluates the roles of genetic variations of hepatitis B virus (HBV) and aflatoxin B(1) (AFB(1)) exposure in the formation of HCC in this high-risk area. METHODS The study recruited 60 HCC patients and 120 age-, gender-, and residency-matched controls. HBV genotype and basic core promoter (BCP) mutations were determined by nested-PCR/direct sequencing. Serum AFB(1… CONTINUE READING