Genetic variations of an oxidase in mammals.

  title={Genetic variations of an oxidase in mammals.},
  author={S. Gluecksohn-waelsch and Paul Greengard and G. P. Quinn and L S Teicher},
  journal={The Journal of biological chemistry},
  volume={242 6},
The genetic basis of the variation in activity of the mammalian enzyme which catalyzes the oxidation of N1-methylnicotinamide to N1-methyl-4-pyridone-3-carboxamide has been investigated. The data indicate that in mice the magnitude of the enzyme activity depends on a pair of autosomal alleles, one of which determines a high level, the other a low level, of enzyme activity. Differences in enzyme activity between males and females and the effect of administration of estradiol and of testosterone… CONTINUE READING